For example, almost 20% of women with an eGFR 45-59 ml/min/1.73 m 2 had cognitive impairment, 33% were partially or fully dependent in two or more activities of daily living and 8% had fallen at least twice during the previous six months. The prevalence of cognitive and functional impairment was by comparison much higher. For example, only 1% of women with an eGFR 45-59 ml/min/1.73 m 2 had hyperphosphatemia and less than 6% had a hemoglobin <11 g/dL. The prevalence of traditional complications of CKD was very low. Baseline characteristics did not differ greatly between those with an eGFR 45-59 ml/min/1.73 m 2 and the referent group with an eGFR ≥ 60 ml/min/1.73 m 2, particularly among women. Among these, most had mild to moderate decrements in eGFR (45-59 ml/min/1.73 m 2) and most were women ( Figure 1). More than half of the members of this cohort had an eGFR < 60 ml/min/1.73 m 2.
#Egfr african american normal range trial
These authors address this question using data collected as part of a randomized trial that compared two methods of multi-dimensional assessment in a representative sample of adults aged 75 and older drawn from primary care practices across Britain. Instead of asking whether older patients with moderate reductions in eGFR do or do not have CKD, they ask whether reductions in eGFR in the elderly are associated with a clinically significant outcome-mortality. In this issue of the American Journal of Kidney Diseases, Roderick and colleagues take a different approach to this issue ( 6). Others point out that reductions in eGFR in the elderly may reflect the high prevalence of kidney disease risk factors at older ages and should not necessarily be considered normal simply because they are common ( 5). Some have argued that such moderate reductions in eGFR can occur as the result of normal aging and should not be equated with chronic kidney disease (CKD) in the absence of other abnormalities ( 2- 4). In the general population, approximately 38% of adults aged 70 or older have an estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m 2, with most having moderate reductions in eGFR in the 30-59 ml/min/1.73 m 2 range ( 1).
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